Interstitial cells of Cajal: update on basic and clinical science.

摘要: The basic science and clinical interest in the networks of interstitial cells Cajal (ICC) keep growing, here, research from 2010 to mid-2013 is highlighted. High-resolution gastrointestinal manometry spatiotemporal mapping are bringing exciting new insights into motor patterns, their function myogenic neurogenic origins, as well role ICC. Critically important knowledge emerging on partaking PDGFRα+ ICC pacemaker networks. Evidence that have unique direct roles muscle innervation. Chronic constipation associated with loss injury ICC, which stimulating extensive maintenance repair after injury. In gastroparesis, high-resolution electrical mechanical studies beginning elucidate pathophysiological system this condition. Receptors ion channels play a being discovered characterized, paves way for pharmacological interventions gut motility disorders through