Simultaneous separation and electroanalysis in a single polydimethylsiloxane-based platform

摘要: Abstract Channel-based microfluidic devices integrating the separation step and detection system are key factors to expand microanalysis application. However, these still depend on macroscale external equipment for pre-treatment of sample, separation, or detection. The integration all steps in only one stage is critical improving feasibility. Herein, we use a low-cost protocol solve part challenge by designing dual-mode onto single polydimethylsiloxane (PDMS)-based platform — overall dimensions 65 mm length × 20 width 14 height inner diameter 297±10 μm 605±19 column-free simultaneous As proof-of-concept, used this all-in-one PDMS separate without packet-based phase determine salicylic acid (SA) caffeine (CAF) with limit 0.20 0.18 μmol L-1 quantification 0.70 0.60 SA CAF, respectively. We separated mixture using forced convection into chemically treated microchannel while detecting analytes amperometric mode. Here, report new insights how further electroanalysis miniaturized device.