作者: F. Chaix , C. Goujard
DOI: 10.1016/J.REVMED.2008.12.014
关键词:
摘要: Since the onset of human immunodeficiency virus (HIV) epidemic, care infected patients improved dramatically. Whereas disease was almost always fatal, development new drugs and therapeutic strategies now allow a prolonged survival. However, complexity patient is increasing physicians face clinical events treatment toxicities. Recent molecules follow-up according to recent French recommendations will be presented here. The objectives decrease mortality morbidity HIV infection, by restoring near normal CD4+ T cell counts qualitative responses, associated with sustained reduction in viral replication. This objective must reached minimizing toxicity antiretroviral drugs. Newly developed that are better-tolerated classes should improve outcome at all stages infection. eradication remains unrealistic protective vaccines not soon available, direct consequences long term infection issues related an ageing population raise up research topics. Prevention infections, improvement precocity better-targeted screening assessment therapy before established immune deficiency appear as main priorities for coming years.