Mechanical Platelet Activation Potential in Abdominal Aortic Aneurysms

摘要: Intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAA) has potential implications to aneurysm growth and rupture risk; yet, the mechanisms underlying its development remain poorly understood. Some researchers have proposed that ILT may be driven by biomechanical platelet activation within AAA, followed adhesion regions of low wall shear stress. Studies investigated stress levels but (AP) not been quantified. In this study, patient-specific computational fluid dynamic (CFD) models were used analyze stress-induced AP AAA under rest exercise flow conditions. The analysis was conducted using Lagrangian particle-based Eulerian continuum-based approaches, results compared. Results indicated is unlikely play a significant role for conditions considered. No consistent trend observed comparing conditions, functional dependence on magnitude exposure time can large impact absolute anticipated AP. method obtained higher peak values, although difference limited small percentage particles falls below reported physiologic background activation.