Gastroesophageal Reflux Disease: Molecular Predictors in Neoplastic Progression of Barrett's Esophagus

摘要: Barrett’s esophagus (BE) represents a metaplastic change from squamous epithelium to intestinal as result of chronic gastroesophagheal reflux. Since the development esophageal adenocarcinoma (EAC) is not universal among patients with BE, it important understand and gauge factors that influence risk progression dysplasia cancer. While heartburn symptoms have been reported be associated BE (Eisen et al., 1997; Lagergren 1999a), severity gastroesophageal reflux reliable indicator for presence (Eloubeidi Provenzale, 2001). There vital need explore other than only may elucidate pathophysiology but also predictive EAC. Significant advances made along key areas such cell cycle abnormalities, growth factors, adiposity, gut microbiome. This chapter aims review some these elements well prognostic value biomarkers The importance fulfilling promise hold underscored by notable increase in cancer 0.5% per year non-dysplastic 13% setting low-grade dysplasia, 40% high-grade (Curvers 2010; Wani 2009).