Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis.

摘要: Optical imaging modalities such as fluorescence (FL) microscopy, multiphoton and optical coherence tomography (OCT) have been well established for high contrast spatial resolution of biological tissues. However, they are dependent on ballistic photons, these methods fail to image beyond ~1 mm or so inside tissue. In contrast, diffuse (DOI), which uses multiple scattered photons imaging, can much deeper (up a several centimeters) into the Unfortunately, due strong light scattering in tissues, it fails maintain at depth. Photoacoustic (PAI) bridges this gap with by combining excitation acoustic detection [1].