Deciphering bioactive peptides and their action mechanisms through proteomics

摘要: ABSTRACTIntroduction: Bioactive peptides such as antimicrobial (AMPs), ribosomally synthesized and post translationally modified (RiPPs) the non-ribosomal (NRPs) have emerged with promising applications in medicine, agriculture industry. However, their development has been limited by several difficulties making it necessary to search for novel discovery methods. In this context, proteomics considered a reliable tool.Areas covered: This review highlights recent developments proteomic tools that facilitate of AMPs, RiPPs NRPs well elucidation action mechanisms AMPs resistance pathogens them.Expert commentary: Proteomic approaches useful study bioactive peptides, especially mass spectrometry-based peptidomics profiling, strategy AMP discovery. Furthermore, rapidly expanding fields genome mining sequencing techniques, spectrome...