Stem Cell–Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters

摘要: Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty chewing and swallowing foods, tooth decay, periodontal disease, microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpine cevimeline) that induce saliva secretion from residual acinar cells as well artificial substitutes. Therefore, advancement of restorative is necessary improve the quality life these patients. Our previous studies indicated able form polarized 3-dimensional structures when grown on growth factor–reduced Matrigel. This basement membrane rich laminin-III (L1), which critical gland formation. Mitotically inactive feeder layers have been used previously support many different cell types, they provide factors organization. The goal study was i...