Pregnancy Exposures Determine Risk of Breast Cancer in Multiple Generations of Offspring

摘要: Breast cancer is the most common non-skin in women United States. The incidence rate of breast among migrant from Asian countries, where low, could achieve States within two generations. Maternal exposures to various environmental factors during pregnancy have been hypothesized be associated with offsprings’ risk. These may change carcinogenesis-related hormone levels and alter epigenome offsprings, which increase their risk later life. effect maternal on via epigenetic modifications carried out through multiple generations offspring. In this chapter, we aim summarize findings both experimental epidemiological studies investigating associations between offspring’s