Method for synthesizing goserelin

摘要: The invention belongs to the field of synthesis medicines, which particularly relates a novel method for synthesizing goserelin by pure liquid-phase fragment method. In goserelin, Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-AZgly-NH2 is formed condensing pentapeptide Pyr-His-Trp-Ser-Tyr-OH and tetrapeptide D-Ser(Tbu)-Leu-Arg-Pro-AZgly-NH2 under existence agent. adopts 5+4 can directly condense into shortens period, avoids rigorous reaction conditions in traditional method, has high yield, good product purity, low cost mild condition suitable industrialized production.