Duration of red blood cell storage and inflammatory marker generation.

摘要: Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs are stored refrigerated in preservative solution, which extends their shelf-life up to 42 days. During storage, the endure abundant physicochemical changes, named RBC storage lesions, affect overall quality standard, functional integrity and vivo survival of transfused RBCs. Some changes occurring early stages period (for approximately two weeks) reversible but become irreversible later on as extended. In this review, we aim decipher duration inflammatory marker generation. This phenomenon included one causes transfusion-related immunomodulation (TRIM), an emerging concept developed potentially elucidate numerous clinical observations that suggest associated with increased events or effects consequence.