Endurance exercise results in DNA damage as detected by the comet assay.

摘要: To determine if 6 weeks of supplementation with antioxidants could alleviate exercise-induced DNA damage, we studied 21 runners during a 50 km ultramarathon. Subjects were randomly assigned to one two groups: (1) placebos (PL) or (2) (AO) (1000 mg vitamin C and 400 IU RRR-alpha-tocopheryl acetate). The comet assay was used assess damage in circulating leukocytes at selected time points: pre-, mid-, 2 h postrace daily for days postrace. All subjects completed the race: run 7.1 +/- 0.1 h, energy expenditure 5008 80 kcal women (n = 10) 6932 206 men 11). Overall, percentage increased midrace (p <.02), but returned baseline by postrace, indicating that exercise bout induced nonpersistent damage. There gender x treatment interaction <.01). One day taking AO had 62% less than PL <.0008). In contrast, there no statistically significant differences between groups any point. Thus, endurance resulted as shown seemed enhance recovery not men.