A series of memantine based salts with various aromatic and aliphatic carboxylic acids: Crystallographic analysis, Hirshfeld surfaces and dissolution study

摘要: Abstract Memantine.HCl (MEM.HCl), an adamantane based amine is a clinically useful drug for the treatment of various neurological disorders. Surprisingly, applications MEM salts/cocrystals in crystal engineering, as supramolecular motif, are rarely reported literature, spite opportunity that salts (primary ammonium monocarboxylate, PAM and primary dicarboxylate, PAD) provide to study reliability stability non-bonded interactions such C–H⋯O, C–H⋯N, van der Waals, etc. presence strong ionic hydrogen bonds (N+ –H…O−, O–H⋯ O, etc.). In present study, new series 12 with varied carboxylic acid backbones (aliphatic aromatic) were synthesized characterized by physicochemical techniques IR, NMR single X-ray studies. The focus was also directed understand synthons these establish structure-property relationship among them. Qualitative (graph set analysis) quantitative (Hirshfeld surface analyses) approaches employed analyse all structures (1A-1K) gain insight regarding assemblies formed some subtle variation well-established PAD synthons. Additionally, subjected solubility studies water compared standard MEM. HCl salt. All displayed range from high medium low Efforts possible cause newly respect backbone, ratio acid/amine (present salts) structures. Moreover, isomerism 1D 0D PAM, bulky group substituted (pivalic 4-methylbenzoic acid), suggests bright future prospects designing materials engineering point view.