Promoting apoptosis of neutrophils and phagocytosis by macrophages: novel strategies in the resolution of inflammation
作者： K Martin , D Ohayon , V Witko-Sarsat
关键词:
摘要: Acute inflammation is the body's response to infection or injury, characterised by rapid infiltration of polymorphonuclear neutrophils site injury followed monocytes, which differentiate locally into macrophages. The latter are essential for removal effete and provided that harmful agent eliminated, will lead resolution inflammation. Perturbations in this process result persistence close control pathways associated with necessary avoid chronic inflammation, autoimmunity, both. As our understanding these processes increase, drugs able trigger pro-resolution may represent an effective strategy treating inflammatory diseases.
smw.ch
emh.ch参考文章(57)
Madhavi J Rane, Jon B Klein, Regulation of neutrophil apoptosis by modulation of PKB/Akt activation Frontiers in Bioscience. ,vol. Volume, pp. 2400- 2412 ,(2009) , 10.2741/3386
Oana Popa-Nita, Sébastien Marois, Philippe Desaulniers, Guillaume Paré, Paul H Naccache, Caroline Gilbert, Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals. The Journal of Rheumatology. ,vol. 33, pp. 928- 938 ,(2006)
Mårten Segelmark, Thomas Hellmark, Pierre Geborek, Mohamed AbdGawad, Lena Gunnarsson, Anders Bengtsson, Studies of mechanisms underlying the prolonged neutrophil survival in ANCA-associated systemic vasculitis Apmis. ,vol. 117, pp. 125- 125 ,(2009)
Sandra Moriceau, Chahrazade Kantari, Julie Mocek, Noélie Davezac, Julie Gabillet, Ida Chiara Guerrera, Frank Brouillard, Danielle Tondelier, Isabelle Sermet-Gaudelus, Claire Danel, Gérard Lenoir, Soizic Daniel, Aleksander Edelman, Véronique Witko-Sarsat, Coronin-1 Is Associated with Neutrophil Survival and Is Cleaved during Apoptosis: Potential Implication in Neutrophils from Cystic Fibrosis Patients Journal of Immunology. ,vol. 182, pp. 7254- 7263 ,(2009) , 10.4049/JIMMUNOL.0803312
Anja K. Schröder, Maren von der Ohe, Ute Kolling, Julia Altstaedt, Peter Uciechowski, Daniela Fleischer, Klaus Dalhoff, XinSheng Ju, Martin Zenke, Nicole Heussen, Lothar Rink, Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators. Immunology. ,vol. 119, pp. 317- 327 ,(2006) , 10.1111/J.1365-2567.2006.02435.X
Véronique Witko-Sarsat, Philippe Rieu, Béatrice Descamps-Latscha, Philippe Lesavre, Lise Halbwachs-Mecarelli, Neutrophils: molecules, functions and pathophysiological aspects. Laboratory Investigation. ,vol. 80, pp. 617- 653 ,(2000) , 10.1038/LABINVEST.3780067
M. Gray, K. Miles, D. Salter, D. Gray, J. Savill, Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 14080- 14085 ,(2007) , 10.1073/PNAS.0700326104
Luke W. Thomas, Connie Lam, Steven W. Edwards, Mcl-1; the molecular regulation of protein function FEBS Letters. ,vol. 584, pp. 2981- 2989 ,(2010) , 10.1016/J.FEBSLET.2010.05.061
Derek W. Gilroy, Toby Lawrence, Mauro Perretti, Adriano G. Rossi, Inflammatory resolution: new opportunities for drug discovery. Nature Reviews Drug Discovery. ,vol. 3, pp. 401- 416 ,(2004) , 10.1038/NRD1383
Chahrazade Kantari, Magali Pederzoli-Ribeil, Omid Amir-Moazami, Valérie Gausson-Dorey, Ivan Cruz Moura, Marie-Christine Lecomte, Marc Benhamou, Véronique Witko-Sarsat, Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis Blood. ,vol. 110, pp. 4086- 4095 ,(2007) , 10.1182/BLOOD-2007-03-080457