The β-Adrenergic Receptor:Elucidation of Its Molecular Structure

摘要: Neurotransmitters and drugs interact with specific receptors in order to produce a cellular response. This recognition of agonists by is the first step an amplification process resulting physiological modulation homeostasis. The concept receptor-mediated mechanism for drug action was proposed Langley (1878, 1905). In 1906, examination Dale various ergot alkaloid compounds preparations led observation number which would inhibit excitatory effects epinephrine without affecting its inhibitory actions. These types observations provided support earliest notions sites catecholamine receptor interactions. 1948, Ahlquist categorically demonstrated using series several sympathomimetic amines one potency stimulating vasoconstriction excitation uterus ureters, different these stimulation vasodilation, inhibition uterine tone, heart. (1948) that actions catecholamines were fact mediated two distinct populations he termed α β, many cases, both are present same organ or tissue. proposal adrenergic has been strongly supported synthesis large potent antagonists clearly α- β- functions. More recent pharmacological studies have resulted further subclassification β-receptors.