Establishment and validation of a nomogram with intratumoral heterogeneity derived from 18 F-FDG PET/CT for predicting individual conditional risk of 5-year recurrence before initial treatment of nasopharyngeal carcinoma

摘要: Intratumoral heterogeneity has an enormous effect on patient treatment and outcome. The purpose of the current study was to establish validate a nomogram with intratumoral derived from 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prognosis 5-Year progression-free survival (PFS) patients nasopharyngeal carcinoma (NPC). A total 171 NPC who underwent pretreatment 18F-FDG PET/CT were retrospectively enrolled. Data randomly divided into training cohort (n = 101) validation (n = 70). clinicopathologic parameters following PET analyzed: maximum mean standardized uptake value (SUVmax, SUVmean), metabolic tumor volume (MTV), lesion glycolysis (TLG), index (HI, SUVmax/SUVmean) primary maximal neck lymph node. Cox analyses performed PFS in cohort. prognostic based this model developed validated. For tumor, MTV-2.5, TLG-2.5, MTV-70%, TLG-70% significantly correlated PFS. node, short diameter HI Among parameters, M stage significant factor recurrence. In multivariate analysis, (P = 0.006), TLG-T-70% (P = 0.002), HI-N (P = 0.018) independent predictors. Based model, generated. C-index 0.74 (95% CI: 0.63–0.85). cross validation, 0.73 0.62–0.83) Patients risk score ≥111 had poorer outcomes than those 0–76 77–110. could predict long-term outcome NPC. combination TNM enables better stratification subgroups different rates.