von Willebrand factor.

摘要: von Willebrand factor is a multimeric glycoprotein essential for the normal arrest of bleeding after tissue injury (hemostasis). The molecule present in blood, both plasma and inside platelets, as well endothelial cells subendothelial matrix vessel wall. Through multiple functional domains, mediates attachment platelets to exposed tissues, where discontinuity vascular endothelium occurs, subsequent platelet aggregation leading formation thrombi. crucial role function particularly apparent when hemodynamic conditions create blood flow with high shear stress, capillaries under physiologic or stenosed partially occluded arteries disease states. involvement processes that lead acute thrombosis has attracted considerable interest on molecular biology protein. Indeed, understanding mechanisms structural bases may result new effective approaches anti-thrombotic intervention.