Abnormal metabolism of postprandial lipoproteins in patients with non-insulin-dependent diabetes mellitus is not related to coronary artery disease.

摘要: To investigate whether abnormalities in alimentary lipemia explain the increased risk of coronary artery disease (CAD) subjects with non-insulin-dependent diabetes mellitus (NIDDM), we performed an oral vitamin A fat-load test four groups men (each n = 15): 1) NIDDM and angiographically verified CAD (DM+CAD+): 2) but no (DM-CAD+); 3) CAD, excluded by exercise thallium scan (DM+CAD-); 4) healthy control (DM-CAD-). The were matched for age body mass index. Plasma obtained after overnight fast 2, 3, 4, 6, 9, 12, 24 h a fatty meal (78 g fat, 345,000 IU retinyl palmitate [RP]) was separated density gradient ultracentrifugation into six fractions triglyceride (TG)-rich lipoproteins: Svedberg flotation units (Sf) > 3200, Sf 1100-3200, 400-1100, 60-400, 20-60, 12-20. TG, RP, cholesterol concentrations measured plasma each lipoprotein fraction. Postprandial TG responses significantly larger both than group. most marked differences observed 60-400 lipoproteins, as or RP responses. However, there between DM+CAD+ DM+CAD- groups. between-group only partially explained fasting levels. In contrast to subjects, significant negative correlation patients lipase activity, implying abnormality lipolysis TG-rich particles NIDDM. Levels atherogenic postprandial remnant lipoproteins are this study magnitude did not distinguish from those without symptoms normal scans.