Proliferation Index Predicts Survival after Second Craniotomy within 6 Months of Adjuvant Radiotherapy for High-grade Glioma

作者: C. Gzell , H. Wheeler , D. Huang , P. Gaur , J. Chen

DOI: 10.1016/J.CLON.2015.08.009

关键词:

摘要: Abstract Aims To determine pathological features that predict survival in patients having repeat craniotomy within 6 months of radiotherapy for high-grade glioma (HGG). Materials and methods HGG (World Health Organization grade 3/4) managed with completing between 2008 2012 were included. Based on the presence residual tumour cells, pathology was reported as progression or pseudoprogression. The proliferation index (Ki67) compared initial a percentage change. Tumour necrosis estimated specimen. Overall calculated months. Results Of 327 HGG, 27 underwent radiotherapy. median after reoperation 11 (95% confidence interval 1–22). Ki67 at 0%, 1–9% >10% associated 13, 13 3 months, respectively ( P  = 0.007). Change also survival, 80% reduction  = 0.02. Widespread treatment-related improved outcome, >80% versus those  = 0.003). Conclusion is not an independent indicator prognosis. Patients had low similar only treatment necrosis. Reduced cells widespread may be more important indicators future outcome.

参考文章(33)
John F. Reavey-Cantwell, Raymond I. Haroun, Marianna Zahurak, Richard E. Clatterbuck, Ricardo J. Parker, Rita Mehta, John P. Fruehauf, Henry Brem, The prognostic value of tumor markers in patients with glioblastoma multiforme: analysis of 32 patients and review of the literature. Journal of Neuro-oncology. ,vol. 55, pp. 195- 204 ,(2001) , 10.1023/A:1013845004294
Ashray Gunjur, Eddie Lau, Yamna Taouk, Gail Ryan, Early post-treatment pseudo-progression amongst glioblastoma multiforme patients treated with radiotherapy and temozolomide: a retrospective analysis. Journal of Medical Imaging and Radiation Oncology. ,vol. 55, pp. 603- 610 ,(2011) , 10.1111/J.1754-9485.2011.02319.X
Xuejun Ma, Jiade Jay Lu, Kwok Seng Loh, Thomas P. Shakespeare, Anu Thiagarajan, Boon Cher Goh, Kim Siang Luke Tan, Role of computed tomography imaging in predicting response of nasopharyngeal carcinoma to definitive radiation therapy. Laryngoscope. ,vol. 116, pp. 2162- 2165 ,(2006) , 10.1097/01.MLG.0000242046.22134.51
Graeme F Woodworth, Tomas Garzon-Muvdi, Xiaobu Ye, Jaishri O Blakeley, Jon D Weingart, Peter C Burger, None, Histopathological correlates with survival in reoperated glioblastomas Journal of Neuro-oncology. ,vol. 113, pp. 485- 493 ,(2013) , 10.1007/S11060-013-1141-3
Gloria B Roldán, James N Scott, John B McIntyre, Marisa Dharmawardene, Paula A De Robles, Anthony M Magliocco, Elizabeth SY Yan, Ian F Parney, Peter A Forsyth, J Gregory Cairncross, Mark G Hamilton, Jacob C Easaw, None, Population-based study of pseudoprogression after chemoradiotherapy in GBM. Canadian Journal of Neurological Sciences. ,vol. 36, pp. 617- 622 ,(2009) , 10.1017/S0317167100008131
Jang-Hee Kim, Young Bae Kim, Jae Ho Han, Kyung-Gi Cho, Se-Hyuk Kim, Seung Soo Sheen, Hyun Woo Lee, Seon-Yong Jeong, Bo Young Kim, Kyi Beom Lee, Pathologic Diagnosis of Recurrent Glioblastoma The American Journal of Surgical Pathology. ,vol. 36, pp. 620- 628 ,(2012) , 10.1097/PAS.0B013E318246040C
Waseet Vance, Susan L. Tucker, Renaud de Crevoisier, Deborah A. Kuban, M. Rex Cheung, The predictive value of 2-year posttreatment biopsy after prostate cancer radiotherapy for eventual biochemical outcome. International Journal of Radiation Oncology Biology Physics. ,vol. 67, pp. 828- 833 ,(2007) , 10.1016/J.IJROBP.2006.09.027
Markus M. Fitzek, Allan F. Thornton, James D. Rabinov, Michael H. Lev, Francisco S. Pardo, John E. Munzenrider, Paul Okunieff, Marc Bussière, Ilana Braun, Fred H. Hochberg, E. Tessa Hedley-Whyte, Norbert J. Liebsch, Griffith R. Harsh, Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial. Journal of Neurosurgery. ,vol. 91, pp. 251- 260 ,(1999) , 10.3171/JNS.1999.91.2.0251
James Fink, Donald Born, Marc C. Chamberlain, Pseudoprogression: relevance with respect to treatment of high-grade gliomas. Current Treatment Options in Oncology. ,vol. 12, pp. 240- 252 ,(2011) , 10.1007/S11864-011-0157-1
Marc C. Chamberlain, Michael J. Glantz, Lisa Chalmers, Alixis Van Horn, Andrew E. Sloan, Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma Journal of Neuro-oncology. ,vol. 82, pp. 81- 83 ,(2007) , 10.1007/S11060-006-9241-Y