作者: C. Gzell , H. Wheeler , D. Huang , P. Gaur , J. Chen
DOI: 10.1016/J.CLON.2015.08.009
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摘要: Abstract Aims To determine pathological features that predict survival in patients having repeat craniotomy within 6 months of radiotherapy for high-grade glioma (HGG). Materials and methods HGG (World Health Organization grade 3/4) managed with completing between 2008 2012 were included. Based on the presence residual tumour cells, pathology was reported as progression or pseudoprogression. The proliferation index (Ki67) compared initial a percentage change. Tumour necrosis estimated specimen. Overall calculated months. Results Of 327 HGG, 27 underwent radiotherapy. median after reoperation 11 (95% confidence interval 1–22). Ki67 at 0%, 1–9% >10% associated 13, 13 3 months, respectively ( P = 0.007). Change also survival, 80% reduction = 0.02. Widespread treatment-related improved outcome, >80% versus those = 0.003). Conclusion is not an independent indicator prognosis. Patients had low similar only treatment necrosis. Reduced cells widespread may be more important indicators future outcome.