Synthesis and structure--mutagenicity relationship of benzo-annulated cyclopentaphenanthrenes.

摘要: Abstract The synthesis of 2,3-dihydro-1 H -indeno[5,4- a ]anthracene ( 2 ), the fluoreno[ ]anthracenes 3 and 4, -cyclopenta[ ]chrysene 6 3,4-dihydro-2-vinylphenanthrene 10 ) cyclopenta[ c ]chrysenes 11 , 12 has been described. Structure analysis new products by 1 13 C NMR spectroscopy is presented. Estimates mutagenic activity compounds – 4 14 in Salmonella typhimurium determined Ames' test indicate that all are inactive for both TA 98 100 strains except 4,5-dihydro-3 ). properties these have compared with those shown previously studied benzo[ g ]cyclopenta[ ]phenanthrenes discussed. Some conclusions drawn about effects benzoannulation carbonyl function on mutagenicity this class compounds.