Intestinal metaplasia of the sinonasal mucosa adjacent to intestinal-type adenocarcinoma. A morphologic, immunohistochemical, and molecular study

摘要: It has been hypothesized that the development of sinonasal intestinal-type adenocarcinoma (ITAC) occurs through intestinal metaplasia (IM) respiratory and/or glandular epithelium. The aim this study was to characterize histological, immunohistochemical, and molecular features IM. Histologic slides from 29 consecutive surgical specimens ITAC were retrieved. Sections stained for CDX2, cytokeratin 20 (CK20), MUC2, p53. status TP53 gene exons 4–9 assessed separately in areas IM ITAC. Foci detected eight cases (27.5 %). They all positive CK20 while MUC2 six (75 In %), metaplastic foci showed signs dysplasia, including nuclear enlargement with increased nucleus cytoplasm ratio, hyperchromasia, loss polarity, presence prominent nucleoli. P53 immunoreactivity observed four cases. sequencing successfully performed revealed same mutation both two (c.832C > T c.215G C), another a not present adjacent (c.536A G). conclusion, our suggests possible clonal relationship between ITAC, indicating may represent precursor lesion Improving knowledge on morphological is key step identify reliable biomarkers determine risk development.