作者: George C. Cotzias
DOI: 10.1001/JAMA.1969.03160330055011
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摘要: Some of the most spectacular drugs in history medicine (digitalis, quinine, penicillin) were discovered when at least two events collided randomly: a biological accident and an observer who happened to be perceptive state. Since such discoveries depend on improbable happenstance, society has not yet proved capable promoting them willfully appreciable degree. By sharp contrast, insulin cortisone developed after slow accumulation data, that subjected later novel interpretation. This approach is one. It is, however, readily amenable promotion by sequential testing hypotheses laboratory wards. latter consideration may justify personal character present account. Background My colleagues I have long been interested metabolism biogenic amines 1,2 essential trace metals like manganese. 3,4 Both classes substances are