Accumulation of Genetic Alterations and Progression of Primary Breast Cancer

摘要: In order to detect common regions of deletion, 219 breast tumors were examined for loss heterozygosity at several loci on chromosomes 3p, 16q, and 17 by restriction fragment length polymorphism analysis. Allelic deletions 13q, 17, amplification the erbB2 oncogene, analyzed compared with histopathological clinical features. Common deletion detected within chromosomal bands 3p13-14.3, 16q22-23, 17p13 (two separated loci), 17q21. Concordant losses alleles 17p, 17q observed. A significant association was between 17p oncogene (17p, P = 0.000721, Fisher's exact test; 17q, < 0.001, x 2 12.135). Furthermore, showing highly malignant phenotypes had accumulated more genetic changes studied than those having less basis classification, lymph node metastasis, tumor size. These results suggested that accumulation alterations, including function suppressor genes may contribute development and/or progression in primary cancer.