Noninvasive motion ventilation (NIMV): a novel approach to ventilatory support

摘要: A motion platform was developed that oscillates an animal in a foot-to-head direction (z-plane). The varies the frequency and intensity of acceleration, imparting periodic sinusoidal inertial forces (pG(z)) to body. aim study characterize ventilation produced by noninvasive ventilator (NIMV) animals with healthy diseased lungs. Incremental increases pG(z) (acceleration) held constant (f = 4 Hz) almost linear minute (VE). Frequencies 2-4 Hz greatest VE tidal volume (VT) for any given acceleration between +/-0.2 +/-0.8 G. Increasing force due proportional both transpulmonary transdiaphragmatic pressures. pressure increasing VT, similar spontaneous breathing. NIMV reversed deliberately induced hypoventilation normalized changes arterial blood gases meconium aspiration. In conclusion, novel is described imparts at moderate frequencies (4 whole body z-plane. These forces, when properly adjusted, are capable highly effective normal Such accomplished airway pressures equivalent atmospheric or continuous positive pressure, less than +/-1 G(z).