Indeterminate diagnosis in fine-needle aspiration of the pancreas: Reasons and clinical implications

摘要: An indeterminate diagnosis made on fine-needle aspiration (FNA) samples of the pancreatic lesions can cause dilemmas in clinical management. We retrospectively analyzed FNA features such 65 consecutive FNAs from 56 to learn more about sources uncertainty and their implications. A definitive based follow-up information was available 50 lesions. Radiologically, 39% showed a cystic component, 25% were ill-defined. Cytologically, contributing factors included scant atypical cells, coexistence gastrointestinal epithelium, pancreatitis, poor cellular preservation, interpretation error. Repeat sampling, as requested by clinicians prior treatment, performed 33 (66%) lesions, leading pathologic 20 (61%) Seventeen eventually resected, which preoperative attempted 12 via repeat sampling successful seven. concluded that cytologic lesion often needs be pursued for optimal Although intrinsic natures component may contribute insufficient diagnostic certainty improved proper specimen handling, interpretation, and/or radiographic correlation.