A Brief Review on 3D Bioprinted Skin Substitutes

摘要: Abstract The global escalating cases of skin donor shortage for patients with severe wounds warn the vital need alternatives to allografts. Over last three decades, research in regeneration area has addressed unmet artificial substitutes. 3D bioprinting is a promising innovative technology accurately fabricate constructs based on natural or synthetic bioinks, whether loaded not native cells (i.e., keratinocytes and fibroblasts) stem prescribed hierarchal structure create multilayer single cell-laden construct. In this paper, recent developments are reviewed discuss different aspects bioprinted substitutes, including printing technology, bioink composition, constructs. impact parameters functionality substitute cell viability provide insight into controlled fabrication as critical component advanced wound healing. We highlight ongoing address progress translation healing from lab clinic.