Organic Anion‐Transporting Polypeptides at the Blood–Brain and Blood–Cerebrospinal Fluid Barriers

摘要: Organic anion‐transporting polypeptides (Oatps) are solute carrier family members that exhibit marked evolutionary conservation. Mammalian Oatps wide tissue expression with an emphasis on in barrier cells. In the brain, expressed blood–brain endothelial cells and blood–cerebrospinal fluid epithelial This profile serves to illustrate a central role for transporting endo‐ xenobiotics across brain chapter will detail patterns substrate specificities of place special emphases prostaglandin synthesis transport conjugated endobiotics.