Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang).
作者： Gabino Garrido , Deyarina Gonz�lez , Carla Delporte , Nadine Backhouse , Gypsy Quintero
DOI: 10.1002/1099-1573(200102)15:1<18::AID-PTR676>3.0.CO;2-R
关键词:
摘要: Vimang is an aqueous extract of Mangifera indica used in Cuba to improve the quality life patients suffering from elevated stress. To assess its possible analgesic and antiinflammatory effects, results a standard evaluation are presented. Analgesia was determined using acetic acid-induced abdominal constriction formalin-induced licking. Antiinflammatory effects were evaluated carrageenan- oedema. (50-1000 mg/kg, p.o.) exhibited potent dose-dependent antinociceptive effect against acid test mice. The mean potency (DE(50)) 54.5 mg/kg maximal inhibition attained 94.4%. (20-1000 dose-dependently inhibited second phase pain but not first phase. DE(50) 8.4 99.5%, being more than indomethacin at doses 20 mg/kg. significantly oedema formation (p < 0.01 or p 0.05) both rat, guinea-pigs mice (maximal inhibitions: 39.5, 45.0 48.6, respectively). inhibitions similar those produced by sodium naproxen, p.o. different polyphenols found could account for actions reported here time M. bark extract.
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