Risk of recurrent molar pregnancies following complete and partial hydatidiform moles

摘要: Study question What is the risk of further molar pregnancies for women with one or more hydatidiform moles (HM) in relation to subtype. Summary answer Women a complete mole (CM) have 1 100 and 4 CM after two consecutive CM, respectively, while partial (PM) only small increase pregnancies. known already pregnancy an increased HM. A subgroup recurrent HM has autosomal recessive condition, familial (FRHM), that predisposes them design, size, duration retrospective study subsequent 16 000 registered at centralized referral centre, PM, between 1990 2009. Participants/materials, setting, methods One hundred sixty-six were identified from electronic records patient notes. Histopathological features all tissue reviewed these cases genotyping performed where diagnosis was not possible on basis histopathological alone. In addition, three establish whether diploid biparental androgenetic. Main results role chance This confirms recurrence ∼1% second addition this associated rather than PM. The data indicate third almost exclusively enabled estimate 640 rare condition FRHM. also found there no significant difference developing gestational trophoblastic neoplasia (GTN) typical sporadic FRHM (GTN; proportion 0.05, Z = 0.87, P 0.29). Limitations, reasons caution While pathology pregnancies, underwent central review particularly those early 1990s. It therefore total number PM may differ slightly stated. followed minimum 5 years, it some subsequently will been included present study. Wider implications findings largest date as such provides most detailed information so far regarding CM. Furthermore, provide new insights into incidence FRHM, important counselling funding/competing interests No competing declared. funding obtained