Diuretic Use, Residual Renal Function, and Mortality Among Hemodialysis Patients in the Dialysis Outcomes and Practice Pattern Study (DOPPS)

摘要: Background Information about residual renal function (RRF) and outcomes associated with practices of diuretic use in patients end-stage disease is not available worldwide. Methods Diuretic was investigated 16,420 hemodialysis from the Dialysis Outcomes Practice Patterns Study, a prospective observational study selected nationally representative facilities on 3 continents. Logistic regressions were used to investigate associations between patient characteristics. interdialytic weight gain, increased serum potassium phosphorus levels, odds retaining RRF after 1 year investigated. Cox regression analyze association mortality use. Results Facility varied substantially 0% 83.9% patients. decreased sharply start dialysis therapy. Loop ranged 9.2% United States 21.3% Europe, whereas within 90 days starting therapy 25.0% 47.6% Japan. lower gain hyperkalemia (potassium > 6.0 mmol/L). Patients had almost twice versus administered diuretics 7% all-cause risk (P = 0.12) 14% cardiac-specific 0.03) diuretics. Conclusion Variation exists facility In RRF, there may be benefit continuing rather than automatically discontinuing at initiation.