The relationship between valproate induced tremors and circulating neurotransmitters: a preliminary study

摘要: Patients with epilepsy and on valproate (VPA) therapy may develop tremors as a common adverse effect; however, its exact mechanisms are unknown. We hypothesize that VPA-induced be related to the disturbances in dopamine (DA) catecholamines (norepinephrine (NE) epinephrine (E)) concentrations (which also involved VPA anticonvulsant effect). aimed determine frequency type of their risk factors investigate whether or not they plasma DA, NE E concentrations. This study included 75 adults primary (mean age: 31.90 ± 5.62 years) for 10.57 3.55 years 40 matched healthy controls. were divided according absence presence tremors. Blood samples analyzed E. Intermittent action both hands reported 31 (41.33%). Chronic standard therapy, older age, longer treatment duration higher serum fact...