The Behavior of Autologous Thyroglobulin in the Circulation of Rabbits Immunized with Either Heterologous or Altered Homologous Thyroglobulin

摘要: Summary Injection of adequate doses NaI 131 into iodine deficient but otherwise normal rabbits results in disruption thyroid structure with release I thyroglobulin the circulation. In these rabbits, is eliminated at an exponential rate a half-life 2.3 days. The autologous previously immunized either arsanil-sulfanil-thyrogobulin (homologous) or heterologous causes secondary stimulation resulting immune elimination and production antibody to native rabbit thyroglobulin. Complexes formed between circulating newly synthesized deposit along glomerular basement membrane kidney mild inflammatory changes proteinuria.