Anaphylaxis and desensitization to the murine monoclonal antibody used for renal graft rejection

摘要: The murine monoclonal antibody muromonab CD3 is currently used to reverse acute renal graft rejection. We report a case of systemic anaphylaxis during infusion despite pretreatment with antihistamines and corticosteroids. Rapid intravenous desensitization was performed the following day without untoward reactions daily infusions were successful in reversing A second rapid 1 month later any complications. Serum CD3-specific IgG IgE antibodies detected serum samples obtained after anaphylactic reaction. reaction muromonoab could have been due allergen-specific noted postreaction or cross-reactive mouse antigens both. More importantly, this illustrates that can be successfully serious complications; therefore, develop susceptible atopic individuals receiving for