Biodistribution and radiation dosimetry of the hypoxia marker 18F-HX4 in monkeys and humans determined by using whole-body PET/CT.

作者: Mohan Doss , James J. Zhang , Marie-José Bélanger , James B. Stubbs , Eric D. Hostetler

DOI: 10.1097/MNM.0B013E3283407950

关键词:

摘要: Objectives 18F-HX4 is a novel positron emission tomography (PET) tracer for imaging hypoxia. The purpose of this study was to determine the biodistribution and estimate radiation dose from 18F-HX4 using whole body PET/CT scans in monkeys humans.

参考文章(18)
Malcolm D. Cooper, Michael J. Wendel, Michael T. Dowd, Peter J. Faulhaber, Chin-Tu Chen, Radiation dose to the bladder wall from 2-[18F]fluoro-2-deoxy-D-glucose in adult humans. The Journal of Nuclear Medicine. ,vol. 32, pp. 707- 712 ,(1991)
Kenneth A. Krohn, Lanell M. Peterson, Jeanne M. Link, Margaret L. Evans, James H. Caldwell, Janet S. Rasey, Michael M. Graham, Wui Jin Koh, Fluorine-18-Fluoromisonidazole Radiation Dosimetry in Imaging Studies The Journal of Nuclear Medicine. ,vol. 38, pp. 1631- 1636 ,(1997)
Michael G Stabin, Eric Crowe, Richard B Sparks, OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. The Journal of Nuclear Medicine. ,vol. 46, pp. 1023- 1027 ,(2005)
Christian W. Tornøe, Caspar Christensen, Morten Meldal, Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Journal of Organic Chemistry. ,vol. 67, pp. 3057- 3064 ,(2002) , 10.1021/JO011148J
Hans Herzog, David Elmenhorst, Oliver Winz, Andreas Bauer, Biodistribution and radiation dosimetry of the A1 adenosine receptor ligand 18F-CPFPX determined from human whole-body PET European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 35, pp. 1499- 1506 ,(2008) , 10.1007/S00259-008-0753-X
Gilles Mees, Rudi Dierckx, Christel Vangestel, Christophe Van de Wiele, Molecular imaging of hypoxia with radiolabelled agents European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 36, pp. 1674- 1686 ,(2009) , 10.1007/S00259-009-1195-9
N Zaffaroni, G Fiorentini, U De Giorgi, Hyperthermia and hypoxia: new developments in anticancer chemotherapy Ejso. ,vol. 27, pp. 340- 342 ,(2001) , 10.1053/EJSO.2000.1040
Yohko Yamazaki, Setsuko Kunimoto, Daishiro Ikeda, Rakicidin A: a hypoxia-selective cytotoxin. Biological & Pharmaceutical Bulletin. ,vol. 30, pp. 261- 265 ,(2007) , 10.1248/BPB.30.261
P.Hugh R. Barrett, Bradley M. Bell, Claudio Cobelli, Hellmut Golde, Alan Schumitzky, Paolo Vicini, David M. Foster, SAAM II: Simulation, Analysis, and Modeling Software for tracer and pharmacokinetic studies. Metabolism-clinical and Experimental. ,vol. 47, pp. 484- 492 ,(1998) , 10.1016/S0026-0495(98)90064-6
Judith van Loon, Marco HM Janssen, Michel Öllers, Hugo JWL Aerts, Ludwig Dubois, Monique Hochstenbag, Anne-Marie C Dingemans, Roy Lalisang, Boudewijn Brans, Bert Windhorst, Guus A van Dongen, Hartmuth Kolb, James Zhang, Dirk De Ruysscher, Philippe Lambin, PET imaging of hypoxia using [18F]HX4: a phase I trial European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 37, pp. 1663- 1668 ,(2010) , 10.1007/S00259-010-1437-X