Methods and Guidance on Health Risk Assessment of Chemical Mixtures

摘要: This half-day workshop presents intermediate topics and hands-on exercises on risk based methodologies for assessing cumulative health from exposure to chemical mixtures, including considerations of multiple route exposures toxicological interactions. Included are limited descriptions basic concepts, the introduction cutting edge mixture assessment issues, explanation state-of-the-art methods, hands several important classes mixtures (e.g., pesticides, metals, drinking water disinfection by-products). Workshop include: procedures definitions selecting among methods; methods incorporating toxicologic interactions data (weight evidence interactions; interaction-based hazard index); discussions issues unique environmental transformations); use physiologically-based pharmacokinetic modeling assessment; integrating relative potency factors with response addition chemicals representing similar dissimilar toxic modes action. The content this includes a general overview evaluation procedures, detailed description new in-depth test sets. Discussions include real world examples, exercise results, application questions comments. Participants asked bring calculator..