Concentration-dependent protein adsorption at the nano-bio interfaces of polymeric nanoparticles and serum proteins.
作者： Tian-Xu Zhang , Guan-Yin Zhu , Bo-Yao Lu , Chao-Liang Zhang , Qiang Peng
关键词:
摘要: AIM A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this have been investigated, like size and ζ potential. However, NPs exposure concentration has always ignored. Herein, we aim to disclose the correlation with protein adsorption. MATERIALS & METHODS Four polymeric systems possessing similar sizes (230 ± 20 nm) but varied potentials (-30 ∼ +40 mv) were prepared. Physicochemical properties adsorption upon NP-protein characterized. RESULTS Protein capacity adsorbed types concentration-dependent. CONCLUSION Considering critical impacts on delivery, our work could be an urgent warning about possible risks dosage adjustment nanoformulations.
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