Synthesis of Pseudopeptides with Sulfoximines as Chiral Backbone Modifying Elements
作者： Carsten Bolm , Guido Moll , Jan D. Kahmann
DOI: 10.1002/1521-3765(20010302)7:5<1118::AID-CHEM1118>3.0.CO;2-3
关键词:
摘要: The synthesis of pseudopeptides with a chiral alpha-sulfonimidoylcarboxy moiety in the backbone is described. Starting from readily available (Ss)-S-methyl S-phenyl sulfoximine and various cyclic acyclic alpha-amino acids desired products are obtained good yields peptide coupling methodology. Specific secondary structures caused by intramolecular hydrogen bonds may be adopted. Results NMR studies to reveal conformational preferences will discussed.
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