Long-Acting Growth Hormone Analogues

摘要: Growth hormone (GH) is an anabolic cytokine regulating linear growth in childhood and normal body composition adults. The current therapeutic regimen for GH replacement requires once-daily subcutaneous injections which inconvenient expensive. A number of approaches have been taken to create long-acting preparations, including depot preparations sustained-release formulations. However, although proven efficacy, such are characterised by a dominant early-release profile, causing supraphysiological levels, manufacture expensive may be painful. There need formulations that minimise manufacturing costs, good pharmacokinetic profiles, easy administer, acceptable patients. Recent focus has on the generation analogues post-translational modification or protein fusions. In this article, we review new technologies generating agonists antagonists pegylation, albumin fusions ligand-receptor