Studies on a procoagulant fraction of southern copperhead snake venom: The preferential release of fibrinopeptide B
作者： John R. Shainoff , John R. Shainoff , Roger H. Herzig , Roger H. Herzig , Oscar D. Ratnoff
DOI: 10.5555/URI:PII:0022214370900557
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摘要: Abstract The venom of the southern copperhead snake ( Ancistrodon contortrix ) possesses procoagulant and fibrinolytic properties. A fraction, separated by chromatography gel filtration, clotted fibrinogen directly possessed proteolytic, esterolytic, amidase activities. In its action upon fibrinogen, fraction released fibrinopeptide B at a much faster rate than A, reverse effect thrombin. Despite rapid release B, visible clotting did not take place until appreciable was also removed. These experiments support view that depends removal from molecule, permitting aggregation monomeric units.
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Arthur M. Siegelman, Arthur S. Carlson, Theodore Robertson, Investigation of serum trypsin and related substances: I. The quantitative demonstration of trypsinlike activity in human blood serum by a micromethod☆ Archives of Biochemistry and Biophysics. ,vol. 97, pp. 159- 163 ,(1962) , 10.1016/0003-9861(62)90058-9
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Torvard C. Laurent, Birger Blombäck, Inga Marie Nilsson, Jaakko Pispa, On the Significance of the Release of Two Different Peptides from Fibrinogen During Clotting. Acta Chemica Scandinavica. ,vol. 12, pp. 1875- 1877 ,(1958) , 10.3891/ACTA.CHEM.SCAND.12-1875
O. D. Ratnoff, E. W. Davie, D. L. Mallett, STUDIES ON THE ACTION OF HAGEMAN FACTOR: EVIDENCE THAT ACTIVATED HAGEMAN FACTOR IN TURN ACTIVATES PLASMA THROMBOPLASTIN ANTECEDENT Journal of Clinical Investigation. ,vol. 40, pp. 803- 819 ,(1961) , 10.1172/JCI104314
Bernard F. Erlanger, Nicholas Kokowsky, William Cohen, The preparation and properties of two new chromogenic substrates of trypsin. Archives of Biochemistry and Biophysics. ,vol. 95, pp. 271- 278 ,(1961) , 10.1016/0003-9861(61)90145-X
F.R. Bettelheim, The clotting of fibrinogen. II. Fractionation of peptide material liberated. Biochimica et Biophysica Acta. ,vol. 19, pp. 121- 130 ,(1956) , 10.1016/0006-3002(56)90393-6
K. LAKI, JULES A. GLADNER, J. E. FOLK, Some aspects of the fibrinogen-fibrin transition. Nature. ,vol. 187, pp. 758- 761 ,(1960) , 10.1038/187758A0
B. Blombäck, M. Blombäck, R.F. Doolittle, B. Hessel, P. Edman, ON THE PROPERTIES OF A NEW HUMAN FIBRINOPEPTIDE. Biochimica et Biophysica Acta. ,vol. 78, pp. 563- 566 ,(1963) , 10.1016/0006-3002(63)90929-6
U. Abildcaard, N-terminal analysis during coagulation of purified human fibrinogen, fraction I, and plasma. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 17, pp. 529- 536 ,(1965) , 10.1080/00365516509083361
J.C. Houck, Y.M. Patel, J. Gladner, The effects of anti-inflammatory drugs upon the chemistry and enzymology of rat skin. Biochemical Pharmacology. ,vol. 16, pp. 1099- 1111 ,(1967) , 10.1016/0006-2952(67)90283-3