Phosphatidylserine on HIV envelope is a cofactor for infection of monocytic cells.

摘要: HIV-1 is an enveloped retrovirus that acquires its outer membrane as the virion exits cell. Because of association apoptosis with progression AIDS, HIV-1-infected T cells or macrophages might be expected to express elevated levels surface phosphatidylserine (PS), a hallmark programmed cell death. Virions produced by these would also predicted have PS on their envelopes. In this study, data are presented support hypothesis and suggest required for macrophage infection. The PS-specific protein annexin V was used enrich virus particles inhibit replication in primary macrophages, but not cells. significantly inhibited vesicles consisting PS, phosphatidylcholine. specifically infection because viruses pseudotyped vesicular stomatitis G amphotropic murine leukemia envelopes were V. These indicate important cofactor macrophages.