Proteoglycans in health and disease: structures and functions.

摘要: General composition and structure Proteoglycans are macromolecules which consist of a protein backbone to GAG chain(s) Nand/or 0-linked oligosaccharides covalently attached (Fig. 1). The chains PGs their linkages core proteins described in Table 1. In the corneal stroma, KS is by linkage kind used attach complex-type highmannose glycoproteins [118]. To all also bound and/or N-linked [81]. have been least well studied components these molecules: this discussed below. complete sequence has so far established for only one PG [20]. view considerable complexity ofPG composition, us organize logical classification scheme we need know not identities constituent GAGs but also, primarily, core-protein sequences. We will now discuss different types known or suspected functions.