Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions.

摘要: Calcium phosphate bions (CPB) are biomimetic mineralo-organic nanoparticles which represent a physiological mechanism regulating the function, transport and disposal of calcium phosphorus in human body. We hypothesised that CPB may be pathogenic entities even cause cardiovascular calcification. Here we revealed isolated from calcified atherosclerotic plaques artificially synthesised morphologically chemically indistinguishable entities. Their formation is accelerated along with increase salts-phosphates/serum concentration ratio. Experiments vitro vivo showed effects defined by apoptosis-mediated endothelial toxicity but not direct tissue calcification or functional changes anti-calcification proteins. Since factors underlying their closely resemble those responsible for atherosclerosis development, further research this direction help us to uncover triggers disease.