Chemical exchange saturation transfer (CEST) signal intensity at 7T MRI of WHO IV° gliomas is dependent on the anatomic location.

摘要: Background Chemical exchange saturation transfer (CEST) is a novel MRI technique applied to brain tumor patients. Purpose To investigate the anatomic location dependence of CEST obtained at 7T and histopathological/molecular parameters in WHO IV° glioma Study type Analytic prospective study. Population Twenty-one patients with newly diagnosed gliomas were studied prior surgery; 11 healthy volunteers investigated. Field strength/sequence Conventional (contrast-enhanced, T2 w diffusion-weighted imaging) 3T was performed for both volunteers. Assessment Mean signal intensities (nuclear-Overhauser-enhancement [NOE], amide-proton-transfer [APT], downfield NOE-suppressed APT [dns-APT]), ADC values, evaluated regard hemisphere contact subventricular zone. cerebral tissue discrimination. Statistical tests Spearman correlation, Mann-Whitney U-test, Wilcoxon signed-rank-test, Fisher's exact test, area under receiver operating curve. Results Maximum dns-APT significantly different right vs. left (P = 0.037 P 0.007), but not subjects 0.062-0.859). values decreased 0.044). NOE intensity did differ between either 0.820), case zone 0.047). A significant correlation observed (rs -0.627, 0.004 rs -0.534, 0.019), -0.341, 0.154). Histopathological/molecular concerning 0.104-1.000, 0.286-0.696). Data conclusion APT, dns-APT, inversely correlated depended on gliomas' location. showed contact. Location dependency APT- NOE-mediated effects should be considered clinical investigations MRI. Level evidence 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;49:777-785.