Historical Review of Combined Experimental and Computational Approaches for Investigating Annulus Fibrosus Mechanics.

摘要: Intervertebral disc research has sought to develop a deeper understanding of spine biomechanics, the complex relationship between health and back pain, mechanisms spinal injury repair. To do so, many researchers have focused on characterizing tissue-level properties disc, where roles tissue subcomponents can be more systematically investigated. Unfortunately, experimental challenges often limit ability measure important tissue- subtissue-level behaviors, including fiber-matrix interactions, transient nutrient electrolyte transport, damage propagation. Numerous theoretical numerical modeling frameworks been introduced explain, complement, guide, optimize efforts. The synergy computational work significantly advanced field, these two aspects continued independently jointly. Meanwhile, become increasingly interdependent. This made it difficult interpret compare results studies, as well solely studies. paper seeks explore issues model translatability, robustness, efficient study design, propose motivate potential future directions for experimental, computational, combined investigations intervertebral disc.