Physagulide Q suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells by regulating the ROS-JAK2/Src-STAT3 signaling pathway

摘要: Physagulide Q (PQ), a new natural compound, was isolated from Physalis angulata L. in our laboratory. In this study, we observed that PQ suppressed cell proliferation and induced apoptosis human hepatocellular carcinoma (HCC) cells. Signal transducer activator of transcription 3 (STAT3) regulates the expression various genes to control cycle progression programmed death. inhibited phosphorylation STAT3 on Tyr705 by suppressing its upstream protein kinases Janus-activated kinase 2 (JAK2) Src. Furthermore, found could induce production reactive oxygen species (ROS) HCC GSH, ROS scavenger, abrogated inhibitory effect JAK2/Src-STAT3 pathway These results suggested signaling through generation