The relationship between vitamin A and risk of fracture: meta-analysis of prospective studies.

摘要: Osteoporotic fracture is a significant cause of morbidity and mortality challenging global health problem. Previous reports the relation between vitamin A intake or blood retinol risk were inconsistent. We searched Medline Embase to assess effects (or beta-carotene but not metabolites) on hip total fracture. Only prospective studies included. pooled data with random meta-analysis adjusted relative (adj.RR) 95% confidence interval (CI). used Q statistic I2 heterogeneity Egger's test publication bias. Eight beta-carotene) (283,930 participants) four level (8725 High shown increase (adj.RR [95% CI] = 1.29 [1.07, 1.57] 1.40 [1.03, 1.91], respectively), whereas was found CI] = 0.82 [0.59, 1.14]). Both high low CI] = 1.87 [1.31, 2.65] 1.56 [1.09, 2.22], respectively). The does differ significantly by retinol) level. Dose-response shows U-shaped relationship serum risk. Our suggests that double-edged sword for To avoid caused too concentration, we suggest (a provitamin A), which should be converted in blood, may better than from meat, directly absorbed into after intake. © 2014 American Society Bone Mineral Research.