TPT1/ TCTP-regulated pathways in phenotypic reprogramming
作者： Robert Amson , Salvatore Pece , Jean-Christophe Marine , Pier Paolo Di Fiore , Adam Telerman
DOI: 10.1016/J.TCB.2012.10.002
关键词:
摘要: Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins closely resembling viral particles. This activates, as do viruses, protein kinase R (PKR). The is structurally similar to mRNA-helicases MSS4. has recently been identified prognostic factor in breast cancer critical regulator of suppressor p53 stem cell (SC) compartment. Emerging evidence indicates that key phenotypic reprogramming, shown process reversion possibly pluripotency. We provide here an overview these diverse functions TPT1/TCTP.
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