Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor
作者： Hiroko Ohki-Hamazaki , Yasushi Sakai , Katsuo Kamata , Hiroo Ogura , Shigeru Okuyama
DOI: 10.1523/JNEUROSCI.19-03-00948.1999
关键词:
摘要: The neuromedin B-preferring receptor (NMB-R) is one of the members bombesin (BN)-like peptide subfamily in mammals. Previously, we have generated and characterized mice with targeted disruption two other BN-like receptors, subtype-3 (BRS-3) gastrin-releasing peptide-preferring (GRP-R). Here describe generation analysis NMB-R-deficient to investigate how NMB-R differs from BRS-3 GRP-R. Compensation for deficiency by overexpression GRP-R and/or was not detected. Although hypothermic effect NMB reduced 50% mice, GRP infusion comparable wild-type mice. In contrast, fundic smooth muscle contraction on stimulation or normal Administration but suppressed glucose intake both These results suggest that has an essential role thermoregulation, fundus suppression feeding behavior. addition, behavioral phenotypes GRP-R-deficient were observed data show functions are distinct, only partial overlap.
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