Effect of NG-monomethyl-L-arginine on kinin-induced vasodilation in the human forearm.

摘要: Abstract 1. We compared effects of NG-monomethyl-L-arginine (L-NMMA), an NO synthase inhibitor, on vasodilator responses to intra-arterial infusion bradykinin and substance P in the human forearm. 2. Bradykinin (100 pmol min-1) increased forearm blood flow when infused into brachial artery eight healthy male volunteers, from 2.8 +/- 0.2 (mean s.e. mean) 9.3 1.0 ml min-1 per 100 volume. 3. Co-infusion L-NMMA (2 mumol 4 with for 6 min produced respectively a 9 14% 42 inhibition (compared vehicle) response bradykinin. 4. Substance (1 further subjects 3.4 6.3 0.7 ml-1. 5. 27 8% 70 13% P. 6. These results demonstrate that both are mediated part via L-arginine/NO pathway. may be useful agonists which study endothelial function this vascular bed.