Retrospective evaluation of autologous bone marrow transplantation vs allogeneic bone marrow transplantation from an HLA identical related donor in acute myelocytic leukemia. A study of the European Cooperative Group for Blood and Marrow Transplantation (EBMT).

摘要: We analyzed retrospectively data from 1696 patients with AML transplanted in Europe January 1987 to December 1992 and reported the acute leukemia EBMT registry. Groups of were according age (adults children) status at transplant (first remission = CR1 ; second CR2). (1) 1114 adult 516 received an allograft 598 autograft. Following alloBMT, transplant-related mortality (TRM) was significantly higher (27 vs 13%, P < 10 -4 ), relapse incidence (RI) lower (25 52%, ) leukemia-free survival (LFS) better (55 42%, 0.006). Favorable prognostic factors for alloBMT a FAB type other than M4-M5, donor-recipient combination excluding female donor male recipient, younger age. ABMT time transplant, AML3 type, longer interval ABMT. (2) 288 CR2 : 98 190 The TRM following allogeneic BMT (32 20%, 0.02) RI (42 63%, 0.001). LFS not different (alloBMT 39% 30%, 0.22). (3) 242 children 129 113 + 5 48 6%, (68 47%, 0.002). use TBI favorable factor allografted LFS. (4) number too small comparative analysis. These results confirm that both autologous are suitable curative approaches AML. They favor HLA identical related when available, especially patients, over unpurged marrow. role purging could be addressed this study.